Progressive keratoconus can be treated by corneal collagen cross-linking (CXL). This one-time, in-office procedure involves the application of a vitamin B solution to the eye, which is then activated by ultraviolet light for about 30 minutes or less. The CXL causes new collagen bonds useful the evolution of the keratoconus.
While the treatment cannot make the cornea entirely normal again, it can keep vision from getting worse and, in some cases, may improve vision.
Cross-linking was approved as a treatment for keratoconus by the FDA in April 2016, after clinical trials showed that it stopped or produced a mild reversal in bulging of the cornea within three to 12 months after the procedure.